DEGRADACIÓN ANORMAL DE P53 E INDUCCIÓN DE APOPTOSIS EN LA RED P53-MDM2 USANDO LA ESTRATEGIA DE CONTROL TIPO PIN

Oscar Suarez, Carlos Vega, Edgar Sanchez, Ana González Santiago, Otoniel Rodríguez Jorge, Aldo Pardo Garcia

Resumen


Este artículo presenta el control tipo “PIN” para regular la actividad de la red p53-Mdm2. Esta red considera la degradación de p53 mediada por el incremento de Mdm2, el cual perturba la respuesta de estrés normal de p53. El modelo considera tres proteínas: p53, Mdm2 y ARF. p53 es regulado a través de un ciclo de retroalimentación que involucra su gen objetivo Mdm2 y un regulador indirecto ARF. Se presentan dos escenarios. Para el primer escenario, la red responde a un incremento de Mdm2 y una baja regulación de p53 sin ninguna entrada externa; luego, en el segundo escenario apoptosis es inducido por el control tipo “PIN”. El comportamiento dinámico de la red y la efectividad del controlador propuesto son ilustrados vía simulaciones.

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DOI: https://doi.org/10.24054/16927257.v32.n32.2018.3020

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