EFECTO GENOTOXICO DEL AGUA RESIDUAL DE LA CURTIEMBRE SAN FAUSTINO-NORTE DE SANTANDER-COLOMBIA
Resumen
Las industrias curtiembres impactan nocivamente el ecosistema por las considerables cantidades de residuos orgánicos y tóxicos que generan, tales como sales y metales pesados; siendo estos últimos, altamente tóxicos, según la IARC (International Agency for Research on Cancer) por inducir efectos mutagénicos y genotóxicos en los seres humanos.
La problemática se presenta por el mal manejo de los desechos, debido a la falta de cultura en la preservación y cuidado de los recursos naturales, la desinformación y la no concientización de las secuelas que se generan, siendo una de las más relevantes que este recurso hídrico contaminado puede llegar a ser usado indiscriminadamente por la población; por tal motivo se hace necesario estimar el impacto ambiental generado. La importancia de este estudio radica en que los desechos de curtiembres ubicadas en la ciudad de Cúcuta, pueden llegar al río Pamplonita, y contaminarlo con metales pesados, como lo reportan estudios realizados en las aguas de desecho de la curtiembre Tasajero.
En este estudio se identificaron los metales pesados (Cr, Pb, Cd, Fe, Zn, Cu) presentes en el agua residual proveniente de la curtiembre San Faustino (Cúcuta), utilizando la técnica de espectroscopia de absorción atómica; encontrándose concentraciones perjudiciales para el ser humano. La mutagenicidad se determninó a través del test de Ames, con las cepas de Salmonella typhimurium TA98 y TA100. Para determinar la genotoxicidad, se usó el ensayo cometa. Se encontró que las aguas de desecho de la curtiembre San Faustino, inducen un incremento en la mutagenicidad en las cepas TA98 y TA100 de Salmonella typhimurium. De igual manera, se encontró que las aguas de desecho de la curtiembre San Faustino, provocan daño al ADN en linfocitos humanos.
Texto completo:
PDFReferencias
Amaral, A.F; Porta, M; Silverman, D.T; Milne, R.L; Kogevinas, M; Rothman, N et al. (2012).Pancreatic cancer risk and levels of trace elements. Gut, 61(11),1583-1588
Ayala MC. (2004). Uso del Ensayo Cometa para Evaluar el Efecto de la Temperatura sobre la Reparación del Daño Genético inducido por Peróxido de Hidrógeno y la Radiación Ultravioleta A en Células Sanguíneas Humanas. Acta Farm. Bonaerense, 23(3), 277-84
Aubier M.(2009). Traffic-related pollutants and their impact on allergic respiratory diseases. Bull. Acad. Natl. Med, 193 (6), 1303–1313 (discussion 1313-1315).
Banjoo, D y Nelson, P.(2005). Improved ultrasonic extraction procedure for the determination of polycyclic aromatic hydrocarbons in sediments. J Chromatogr A, 1066,(1-2),9-18.
Brunekreef, B; Holgate, S.T.(2002). Air pollution and health. Lancet, 360,1233–1242
Cancio, J.L; Castellano, A.V; Hernández, M.C; Bethencourt, R.G; Ortega, E.M.(2008). Metallic species in atmospheric particulate matter in Las Palmas de Gran Canaria. Journal of Hazardous Materials,160,521–528
Castro, D; Slezakova, K; Oliva–Teles, M.T; Delerue–Matos, C; Alvim–Ferraz, M.C; Morais, S. et al.(2009). Analysis of polycyclic aromatic hydrocarbons in atmospheric particulate samples by microwave–assisted extraction and liquid chromatography. J. Sep. Sci, 32(4), 501–510
Courter, L.A; Luch, A; Musafia-Jeknic, T; Arlt, V.M; Fischer, K; Bildfell, R. et al.(2008). The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo. Cancer Lett,265,135–147.
Cohen, A.J; Pope, C.A.(1995). Lung cancer and air pollution. Environ. Health Perspec,103 (Suppl), 219–224.
Claxton, L.D; Warren, S; Zweidinger, R; Creason, J.(2001). A comparative assessment of Boise, Idaho, ambient air fine particle samples using the plate and microsuspension Salmonella mutagenicity assays. Sci. Total Environ , 275,95–108.
Da Costa, G.G; Singh,R; Arlt, V.M; Mirza, A; Richards, M; Takamura-Enya, T. et al. (2009).Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry. Chemical Research in Toxicology, 22(1),1860-1868.
Fukino, H; Mimura, S; Inoue, K; Yamane, Y.(1982). Mutagenicity of airborne particles. Mutat. Res,102, 237–247
Franco, S.S; Nardocci, A.C; Gunther, W.M.(2008). PAH biomarkers for human health risk assessment: a review of the state of the art. Cad. Saude. Publica , 24 (Suppl.4), s569–580.
Goldberg, M.S; Burnett, R.T; Bailar, J.C; Brook, J; Bonvalot, Y; Tamblyn, R. et al. .(2001).The association between daily mortality and ambient air particle pollution in Montreal, Quebec. Environ. Re,86(1),26–36
Guo, H; Lee, S.C; Ho, K.F; Wang, X.M; Zou, S.C.(2003). Particle-associated polycyclic aromatic hydrocarbons in urban air of Hong Kong, Atmos. Environ,37, 5307–5317.
Huang,W; Smith, T.J; Ngo, L; Wang, T; Chen, H; Wu, F. et al.(2007). Characterizing and biological monitoring of polycyclic aro-matic hydrocarbons in exposures to diesel exhaust. Environ. Sci. Technol ,41,2711–2716.
IARC (1987). (International Agency for Research on Cancer), Overall evaluations of carcinogenicity; an updating of IARC monographs Volumes 1–42. IARC, Lyon.
Karaman, A; Pirim, I.(2009). Exposure to bitumen fumes and genotoxic effects on Turkish asphalt workers. J. Clin. Toxicol, 47,321–326.
Kuo, C.Y; Cheng, Y.W; Chen, C.Y; Lee, H.(1998). Correlation between the amounts of polycyclic aromatic hydrocarbons and mutagenicity of airborne particulate samples from Taichung City, Taiwan, Environ. Res,78, 43–49.
Klaunig, J.E; Kamendulis, L.M.(2004). The role of oxidative stress in carcinogenesis. Ann. Rev. Pharmacol. Toxicol,44,239–267.
Li, N; Hao, M; Phalen, R.F; Hinds, W.C; Nel, A.E.(2003). Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clinical Immunology,109(3),250-65.
Mari, M; Nadal, M; Domingo, J.L.(2009). Exposure to heavy metals and PCDD/Fs by the population living in the vicinity of a hazardous waste landfill in Catalonia, Spain. Health risk assessment. Environ Int ,35,1034-1039.
Matés, J.M; Segura, J.A; Alonso, F.J; Marquéz, J.(2010). Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms. Free Radical Biology and Medicine,49(9),1328-1341.
Milaeva, E.R.(2011). Metal-based antioxidants--potential therapeutic candidates for prevention the oxidative stress-related carcinogenesis: mini-review. Curr Top Med Chem,11(21),2703-13.
Misaki, K; Suzuki, M; Nakamura, M; Handa, H; Iida, M; Kato, T; et al.(2008). Aryl hydrocarbon receptor and estrogen receptor ligand activity of organic extracts from road dust and diesel exhaust particulates. Arch. Environ.Contam. Toxicol, 55,199–209.
Mumford, J.L y Lewtas, J.(1984). Evaluation of fly ash collection methods for short-term bioassay studies of fluidized-bed coal combustion, Environ. Sci. Technol,18, 765–768,
Nguyen, Thi. Hieu y Byeong-Kyu, Lee.(2010).Characteristics of particulate matter and metals in the ambient air from aresidential area in the largest industrial city in Korea. Atmospheric Research,98,526–537
Pagano, P; de Zaiacomo, T; Scaecella, E; Bruni, E.S; Calamosca, M.(1996). Mutagenic activity of total and particle-sized fractions of urban particulate matter. Environ. Sci. Tech, 30(12), 3512–3516
Pope III, C.A; Burnett, R.T; Thun, R.T; Calle, E.E; Krewsi, D; Ito, K. et al.(2002). Lung cancer, cardiopulmonary mortality and long-term exposure to fine particulate air pollution. J. Am. Med,287(9),1132–1141
Ping, L y Panuwat, H.(2006). Characterization of polycyclic aromatic hydrocarbons (PAHs) on lime spray dryer (LSD) ash using different extraction methods. Chemosphere,62,265-274.
Quijano Parra, A; Quijano Vargas, M.J; Henao Martinez, J.A.(2010). Caracterización fisicoquímica del material particulado fracción respirable del PM2.5 en Pamplona Norte de Santander. Bistua: revista de la facultad de Ciencias Basicas,8(1),1-20
Ravindra, K; Bencs, L; Wauters, E; de Hoog, J; Deutsch, F; Roekens, E. et al. (2006).Seasonal and site‐specific variation in vapour and aerosol phase PAHs over Flanders (Belgium) and their relation with anthropogenic activities. Atmospheric Environment,40,771‐785.
Riger, C.J; Fernandes, P.N; Vilela, L.F; Mielniczki-Pereira,A.A;Bonatto, D; Henriques, J.A. et al.(2011). Evaluation of heavy metal toxicity in eukaryotes using a simple functional assay. Metallomics ,3(12),1355-1356
Ryno, M; Rantanen, L; Papaioannou, E; Konstandopoulos, A.G; Koskentalo, T; Savela, K.(2006). Comparison of pressurized fluid extraction, Soxhlet extraction and sonication for the determination of polycyclic aromatic hydrocarbons in urban air and diesel exhaust particulate matter. J. Environ. Monit, 8,488–493.
Sevastyanova,O; Novakova,Z; Hanzalova, K; Binkova, B; Sram, R.J; Topinka, J. (2008).Temporal variation in the genotoxic potential of urban air particulate matter. Mutat. Res,649,179–186
Singh, P; De Marini, D.M; Dick, C.A.J; Tabor, V.J.V; Ryan, W.P; Linak, T. et al. (2004).Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice. Environ. Health Perspect,112,820–825
Slezakova, K; Castro, D; Delerue–Matos, C; Alvim–Ferraz, M.C; Morais, S; Pereira, M.C.(2011). Air pollution from traffic emissions in Oporto, Portugal: Health and environmental implications. Microchem. J,99,51–59
Slezakova, K; Castro, D; Pereira, M.C; Morais, S; Delerue-Matos, C; Alvim-Ferraz, MCM.(2010). Influence of traffic emissions on the carcinogenic polycyclic aromatic hydrocarbons in outdoor breathable particles. J. Air Waste Manag Assoc,60, 393– 401.
Shah, M.H; Shaheen, N; Jaffar, M; Khalique, A; Tariq, S.R; Manzoor, S.(2006). Spatial variations in selected metal contents and particle size distribution in an urban and rural atmosphere of Islamabad, Pakistan. Journal of Environmental Management, 78, 128–137
Shaheen, N; Shah, M.H; Khalique, A; Jaffar, M.(2005). Metal levels in airborne particulate matter in urban Islamabad, Pakistan. Bulletin of Environmental Contamination and Toxicology,75(4),739–746
Shultz, C.A; Quinn, A.M; Park, J.H; Harvey, R.G; Bolton, J.L; Maser, E. et al. (2011).Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chem. Research. Tox-icol,24,2153–2166.
Spencer, W.A; Lehmler, H.J; Robertson, L.W; Gupta, R.C.(2009). Oxidative DNA adducts after Cu(2+)-mediated activation of dihydroxy PCBs: role of reactive oxygen species. Free Radical Bio. Med,46,1346–1352.
Taga, R; Tang, N; Hattori, T; Tamura, K; Sakai, S; Toriba, A; et al.(2005). Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbons Mutat. Res,581(1-2),91–95
Taguchi, K; Fujii, S; Yamano, S; Cho, A.K; Kamisuki, S; Nakai, Y. et al.(2007). An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radical Biol. Med,43,789–799.
US EPA (2012). (United States Environmental Protection Agency), Integrated risk information system. Benzo[a]pyrene (BaP) (CASRN 50-32-8). U.S. Environmental Protection Agency, Washington, DC. http://www.epa.gov/iris/subst/0136.htm,2012 (accessed 11.12.2012).
Valavanidis, A; Fiotakis, K; Vlachogianni, T.(2008). Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J. Environ. Sci. Health. C. Environ. Carcinog. Ecotoxicol. Rev 2008; 26(4),339–362.
Vinitketkumnuen, U; Kalayanamitra, K; Chewonarin, T; Kamens, R.(2002). Particulate matter, PM10 & PM2.5 levels, and airborne mutagenicity in Chiang Mai, Thailand. Mutat. Res, 519,121–131
Wada, M; Kido, H; Kishikawa, N; Tou, T; Tanaka, M; Tsubokura, J. et al.(2001). Assessment of air pollution in Nagasaki city: determination of polycyclic aromatic hydrocarbons and their nitrated derivatives, and some metals. Environ. Pollut, 115,139–147.
Yang,X.Y; Igarashi, K; Tang, N; Lin, J.M; Wang, W; Kameda, T; Toriba, A; Hayakawa K.(2010). Indirect- and direct-acting mutagenicity of diesel, coal and wood burning-derived particulates and contribution of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons. Mutat Res,695(1-2),29-34.
Zidzik, J; Kalina, I; Salagovic, J; Sram, R.J; Rossner, P; Popov, T. et al.(2007). Influence of PAHs in ambient air on chromosomal aberrations in exposed subjects: international study – EXPAH. Mutat. Res,620(1-2),41-8
Zmirou, D; Masclet, P; Boudet, C; Dor, F; Dechenaux, J.(2000). Personal exposure to atmospheric polycyclic hydrocarbons in a general adult population and lung cancer risk assessment. J. Occup. Environ. Cancer Risk Assess,4,121–126
Zhang, L; Jin,Y; Huang, M; Penning, T.M.(2012). The role of human aldo-keto reductases in the metabolic activation and detoxication of polycyclic aromatic hydrocarbons: interconversion of PAH catechols and PAH o-quinones. Front.Pharmacol, 3, 193.
Zheng, Na;Jingshuang, L; Qichao, W;, Zhongzhu, L.(2010). Health risk assessment of heavy metal exposure to street dust in the zinc smelting district, Northeast of China. Science of the Total Environment, 408,726–733.
DOI: https://doi.org/10.24054/16927257.v32.n32.2018.3021
Enlaces refback
- No hay ningún enlace refback.
Comentarios sobre este artículo
por rifki abdul rojok Hj Onta Bocor (2018-11-30)
por christhanah 3 (2019-01-06)
por kalam kumar (2019-01-08)
por greecefelicia greece gf felicia (2019-01-13)
por greecefelicia greece gf felicia (2019-01-13)
por greecefelicia greece gf felicia (2019-01-13)
por zuwehivac zuwehivac (2019-01-23)
por Sebab Gagalnya Proses Daftar Pada Situs Judi Online (2019-01-30)
por cynthia lee (2019-01-30)
por welcome Ratna Dewi (2019-02-01)
por Michelle Alegria (2019-02-08)
por Jesika Sihotang (2019-02-08)
por greecefelicia greece gf felicia (2019-02-08)
por Gisella Nanda (2019-02-08)
por Stefannie Jen (2019-02-14)
por Ayu Nita (2019-02-14)
por key flower (2019-02-22)
por armelia sunz (2019-02-24)
por Vinisia Helen (2019-02-24)
por greecefelicia greece gf felicia (2019-03-03)
por greecefelicia greece gf felicia (2019-03-03)
por Daftar Sbobet Online Terpercaya Daftar Sbobet (2019-03-07)
por trustteam 6 (2019-03-14)
por Sujoy Thakur (2019-03-18)
por Baby Margaret (2019-03-18)
por Dewi Shinta (2019-05-23)
por Domino Pro99 (2019-12-13)
por Candace Move (2020-02-22)
por bl hitamputih (2020-03-09)